- 06-March-1957 : United Kingdom colonies Gold Coast and British Togoland become the independent nation of Ghana.
- 10-October-1957 : U.S. President Dwight D. Eisenhower apologizes to the finance minister of Ghana, Komla Agbeli Gbdemah, after he is refused service in a Dover, Delaware restaurant.
- 03-February-1960 : In Greensboro, North Carolina, four black students from North Carolina Agricultural and Technical State Universitye Universitybegin a sitsitin at a segregated Woolworth's lunch counter. Although they are refused service, they are allowed to stay at the counter. The event triggers many similar nonviolent protests throughout the Southern United States, and 6 months later the original 4 protesters are served lunch at the same counter.
Prime Minister of the United Kingdom Harold Macmillan makes the Wind of Change speech to the South African Parliament in Cape Town (although he had first made the speech, to little publicity, in Accra, Gold Coast now Ghana on January 10).
- 01-July-1960 : Ghana becomes a republic and Kwame Nkrumah becomes its first President as Queen Elizabeth II of the United Kingdom ceases to be the head of state.
- 07-January-1961 : Following a 44day conference in Casablanca, 5 African chiefs of state announce plans for a NATONATOtype African organization to ensure common defense. The Charter of Casablanca involves the Casablanca Group: Morocco, the United Arab Republic, Ghana, Guinea, and Mali.
- 05-December-1961 : U.S. President John F. Kennedy gives support to the Volta Dam project in Ghana.
- 24-February-1966 : A military coup in Ghana raises sacked General Ankrah to power while president Kwame Nkrumah is abroad.
- 29-October-1966 : The Guinean delegation to the OAU meeting in Ethiopia, become hostages of the Ghanaian government in Accra.
- 13-January-1972 : Prime Minister of Ghana Kofi Abrefa Busia is overthrown in a military coup.
- 04-June-1979 : Flight Lieutenant Jerry Rawlings takes power in Ghana after a military coup in which General Akuffo is overthrown.