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| Royal Colony of North Carolina - 20-February-1740 : The North Carolina General Assembly incorporates the town of Newton as Wilmington, North Carolina, named for Spencer Compton, 1st Earl of Wilmington, and patron of Royal Governor Gabriel Johnston.
- 27-February-1760 : Seven Years' War French and Indian War: Cherokee natives allied with French forces attack a North Carolina militia stationed at Fort Dobbs in the western part of the province. The attack is repelled by the militia.
- 01-February-1763 : The Royal Colony of North Carolina officially creates Mecklenburg County from the western portion of Anson County. The county is named for Queen Charlotte of Mecklenburg-Strelitz, who married King George III in 1761.
- 17-October-1765 : The ''Pennsylvania Gazette'' reports that a Mr. McCullough, the Distributor of Stamps for the Royal Colony of North Carolina, has resigned his post in protest of the Stamp Act. A Dr. Huston is appointed to the position.
- 05-February-1766 : An observer in Wilmington, North Carolina reports to the Edinburgh newspaper ''Caledonian Mercury'' that 3 ships were seized by British menmenofofwar on the charge of carrying official documents without stamps. The strict enforcement causes 7 other ships to leave Wilmington for other ports.
- 09-January-1767 : William Tryon, governor of the Royal Colony of North Carolina, signs a contract with architect John Hawks to build Tryon Palace, a lavish Georgian style governor's mansion on the New Bern waterfront.
- 27-February-1776 : American Revolution: Battle of Moore's Creek Bridge: North Carolina Loyalists charge across Moore's Creek bridge near Wilmington to attack what they mistakenly believe to be a small force of rebels. Several loyalist leaders are killed in the ensuing battle. The patriot victory virtually ends all British authority in the town.
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