- 06-February-1952 : In the United States, a mechanical heart is used for the first time in a human patient.
- 08-April-1952 : ''Youngstown Sheet & Tube Co. v. Sawyer'': The U.S. Supreme Court limits the power of the President to seize private business, after President Harry S. Truman nationalizes all steel mills in the United States, just before the 1952 steel strike begins.
- 29-April-1952 : Lever House officially opens in New York City, heralding a new age of commercial architecture in the United States.
- 25-July-1952 : Puerto Rico becomes a selfselfgoverning commonwealth of the United States.
- 01-November-1952 : Nuclear testing: Operation Ivy: The United States successfully detonates the first hydrogen bomb, codenamed "Mike", at Eniwetok Atoll in the Marshall Islands in the central Pacific Ocean, with a yield of 10.4 megatons.
- 07-January-1953 : President Harry S. Truman announces the United States has developed a hydrogen bomb.
- 19-January-1953 : 68 of all television sets in the United States are tuned in to ''I Love Lucy'' to watch Lucy give birth.
- 19-February-1953 : Georgia approves the first literature censorship board in the United States.
- 25-May-1953 : Nuclear testing: At the Nevada Test Site, the United States conducts its first and only nuclear artillery test.
- 27-July-1953 : The Korean War ends: The United States, People's Republic of China, North Korea, and South Korea sign an armistice agreement.